Psychiatric Disorders in America: The Epidemiologic Catchment Area Study 1st Edition
Author: Lee N. Robins ID: 0029265711
Hardcover: 449 pagesPublisher: Free Press; 1 edition (November 1, 1990)Language: EnglishISBN-10: 0029265711ISBN-13: 978-0029265710 Product Dimensions: 9.6 x 6.5 x 1.7 inches Shipping Weight: 2 pounds Best Sellers Rank: #1,951,063 in Books (See Top 100 in Books) #819 in Books > Medical Books > Basic Sciences > Biostatistics #1412 in Books > Medical Books > Research #1729 in Books > Textbooks > Medicine & Health Sciences > Administration & Policy > Public Health
Psychiatric Disorders in America The Epidemiologic Psychiatric Disorders in America The Epidemiologic Catchment Area Study Psychiatric Disorders in America The Epidemiologic Catchment Area Study 1st EditionPsychiatric Disorders in America The Epidemiologic Psychiatric Disorders in America Psychiatric Disorders in America The Epidemiologic Catchment Area Study has 1 available editions to buy 1st edition Psychiatric disorders in America the epidemiologic the epidemiologic catchment area study in America the epidemiologic catchment area Medical Public Health Mental Disorders epidemiology Psychiatric Disorders in America Medical Books Mar 08 2011 Psychiatric Disorders in America The Epidemiologic Catchment Area Psychiatric Disorders In America Epidemiologic Catchment Area Study
Download Psychiatric Disorders in America: The Epidemiologic Catchment Area Study 1st Edition Pdf Download
Those Who Leave and Those Who Stay Audible – Unabridged ridged
Author: Elena Ferrante ID: B00XRCDEME
The incredible story continues in book 3 of the critically acclaimed Neapolitan novels! In this third Neapolitan novel, Elena and Lila, the two girls whom were first introduced in My Brilliant Friend, have become women. Lila married at sixteen and has a young son; she has left her husband and the comforts her marriage brought and now works as a common laborer. Elena has left the neighborhood, earned her college degree, and published a successful novel, all of which has opened the doors to a world of learned interlocutors and richly furnished salons. Both women are pushing against the walls of a prison that would have seen them living a life of misery, ignorance, and submission. They are afloat on the great sea of opportunities that opened up during the 1970s. Yet they are still very much bound to each other by a strong, unbreakable bond.
Done.
Audible Audio EditionListening Length: 16 hours and 48 minutesProgram Type: AudiobookVersion: UnabridgedPublisher: Blackstone AudioAudible.com Release Date: May 15, 2015Whispersync for Voice: ReadyLanguage: EnglishID: B00XRCDEME Best Sellers Rank: #607 in Books > Audible Audiobooks > Fiction & Literature #787 in Books > Literature & Fiction > Literary #943 in Books > Literature & Fiction > Women’s Fiction > Contemporary Women
It appears that Elena Ferrante is intent upon surprising her readership constantly not only in the intensity and complexity of her work, but also in the form. It had been anticipated that this book would be the capstone of her Naples trilogy, the other two books being "My Brilliant Friend" and "The Story of a New Name." This is not the case since the ending of this book indulges the reader by indicating that a fourth "Naples volume" is in the making.
This book indicates that her ambition is almost Proustian or Faulknerian in scope for this series. There is the continuation of the tortured relationship between the narrator Elena and her childhood friend Lila and the ebb and flow of all the tributaries that haunt these two, whether it be the old neighborhood, the mangled relationships of old lovers, families, regional disputes etc. Where this volume diverges from the other two is that there is more theoretical talk between Elena, Lila, and Elena’s lover and her husband. When a writer has a character talk about the art of writing and the creative process, you should pay close attention to those sections.Yet this novel does not yield an inch to its predecessors in dramatic intensity and I feel that it surpasses them substantially.
Not only is there an intensity but also an urgency conveyed in this book that accelerates to the last chapter which ends with all the force of old Hollywood cliffhangers. However whereas the other two books in this series could almost be read as stand-alone works, this one does require that the reader to have acquainted himself with the at least the second book in the series.
There is a constant sense of wonder in that Ms.
I did not think Volume Three of this extraordinary soon to be tetralogy was up to the standards of the first two books. Then again, perhaps I am just getting tired, as I have read all three over the last few weeks. As that fact indicates, I did find the work gripping, and Volume Three was no different at least through the middle of the book.
As usual, the emotional link between the two women, now in their twenties and early thirties is intense, and vividly rendered. Beyond that, the depiction of the union organizing and fascist and anti-fascist strife was done very well. I have read little like it.
Nevertheless, for me this whole series has major flaws. While it is very upscale chick lit and an entertaining read, perhaps the stuff of a major television mini-series, this is not great literature. There is far too much dependence on mindless coincidence. Simlarly, the introduction of Elena’s younger sister Elisa as an important character late in the book, without any preparation is a major flaw. As usual, for the most part, the minor characters are only lightly drawn and are virtually indistinguishable.
But it is the major characters who gave me most pause. Lila becomes in this volume nearly a character out of science fiction. She has almost superhuman powers. She is prescient, beautiful, and every man falls ineluctably in love with/lusts after her. It is too much. Similarly, after three volumes and 1200 pages, it is clear that Elena is stuck on the womanizer Nino, but I defy anyone to tell me why. There is no basis for it outside of Elena’s psyche, and she is not sharing that with us.
The action is melodramatic, operatic. The attempts at explanation of the ladies’ feelings are sophistical.
Ashes Ashes Trilogy Series 1 by Ilsa J Bick where those left standing must learn what a backpacking trip in the wilderness when something unexpected and terrifying happens ndash Angelfall Penryn and the End of Days Series 1 by It will satisfy those looking for Susan Ee has said there should be about five books in the Penryn and the End of Days series ndash Susan Ee continued to Bones TV Series 2005 IMDb Booth struggles to protect those closest to him Bones 2005 browse photos track your Watchlist and rate your favorite movies and TV shows on your
Download Those Who Leave and Those Who Stay Audible – Unabridged ridged Free PDF
Psychiatric Disorders in America: The Epidemiologic Catchment Area Study 1st Edition
Author: Lee N. Robins ID: 0029265711
Hardcover: 449 pagesPublisher: Free Press; 1 edition (November 1, 1990)Language: EnglishISBN-10: 0029265711ISBN-13: 978-0029265710 Product Dimensions: 9.6 x 6.5 x 1.7 inches Shipping Weight: 2 pounds Best Sellers Rank: #1,951,063 in Books (See Top 100 in Books) #819 in Books > Medical Books > Basic Sciences > Biostatistics #1412 in Books > Medical Books > Research #1729 in Books > Textbooks > Medicine & Health Sciences > Administration & Policy > Public Health
Psychiatric Disorders in America The Epidemiologic Psychiatric Disorders in America The Epidemiologic Catchment Area Study Psychiatric Disorders in America The Epidemiologic Catchment Area Study 1st EditionPsychiatric Disorders in America The Epidemiologic Psychiatric Disorders in America Psychiatric Disorders in America The Epidemiologic Catchment Area Study has 1 available editions to buy 1st edition Psychiatric disorders in America the epidemiologic the epidemiologic catchment area study in America the epidemiologic catchment area Medical Public Health Mental Disorders epidemiology Psychiatric Disorders in America Medical Books Mar 08 2011 Psychiatric Disorders in America The Epidemiologic Catchment Area Psychiatric Disorders In America Epidemiologic Catchment Area Study
Download Psychiatric Disorders in America: The Epidemiologic Catchment Area Study 1st Edition Pdf Download
Those Who Leave and Those Who Stay Audible – Unabridged ridged
Author: Elena Ferrante ID: B00XRCDEME
The incredible story continues in book 3 of the critically acclaimed Neapolitan novels! In this third Neapolitan novel, Elena and Lila, the two girls whom were first introduced in My Brilliant Friend, have become women. Lila married at sixteen and has a young son; she has left her husband and the comforts her marriage brought and now works as a common laborer. Elena has left the neighborhood, earned her college degree, and published a successful novel, all of which has opened the doors to a world of learned interlocutors and richly furnished salons. Both women are pushing against the walls of a prison that would have seen them living a life of misery, ignorance, and submission. They are afloat on the great sea of opportunities that opened up during the 1970s. Yet they are still very much bound to each other by a strong, unbreakable bond.
Done.
Audible Audio EditionListening Length: 16 hours and 48 minutesProgram Type: AudiobookVersion: UnabridgedPublisher: Blackstone AudioAudible.com Release Date: May 15, 2015Whispersync for Voice: ReadyLanguage: EnglishID: B00XRCDEME Best Sellers Rank: #607 in Books > Audible Audiobooks > Fiction & Literature #787 in Books > Literature & Fiction > Literary #943 in Books > Literature & Fiction > Women’s Fiction > Contemporary Women
It appears that Elena Ferrante is intent upon surprising her readership constantly not only in the intensity and complexity of her work, but also in the form. It had been anticipated that this book would be the capstone of her Naples trilogy, the other two books being "My Brilliant Friend" and "The Story of a New Name." This is not the case since the ending of this book indulges the reader by indicating that a fourth "Naples volume" is in the making.
This book indicates that her ambition is almost Proustian or Faulknerian in scope for this series. There is the continuation of the tortured relationship between the narrator Elena and her childhood friend Lila and the ebb and flow of all the tributaries that haunt these two, whether it be the old neighborhood, the mangled relationships of old lovers, families, regional disputes etc. Where this volume diverges from the other two is that there is more theoretical talk between Elena, Lila, and Elena’s lover and her husband. When a writer has a character talk about the art of writing and the creative process, you should pay close attention to those sections.Yet this novel does not yield an inch to its predecessors in dramatic intensity and I feel that it surpasses them substantially.
Not only is there an intensity but also an urgency conveyed in this book that accelerates to the last chapter which ends with all the force of old Hollywood cliffhangers. However whereas the other two books in this series could almost be read as stand-alone works, this one does require that the reader to have acquainted himself with the at least the second book in the series.
There is a constant sense of wonder in that Ms.
I did not think Volume Three of this extraordinary soon to be tetralogy was up to the standards of the first two books. Then again, perhaps I am just getting tired, as I have read all three over the last few weeks. As that fact indicates, I did find the work gripping, and Volume Three was no different at least through the middle of the book.
As usual, the emotional link between the two women, now in their twenties and early thirties is intense, and vividly rendered. Beyond that, the depiction of the union organizing and fascist and anti-fascist strife was done very well. I have read little like it.
Nevertheless, for me this whole series has major flaws. While it is very upscale chick lit and an entertaining read, perhaps the stuff of a major television mini-series, this is not great literature. There is far too much dependence on mindless coincidence. Simlarly, the introduction of Elena’s younger sister Elisa as an important character late in the book, without any preparation is a major flaw. As usual, for the most part, the minor characters are only lightly drawn and are virtually indistinguishable.
But it is the major characters who gave me most pause. Lila becomes in this volume nearly a character out of science fiction. She has almost superhuman powers. She is prescient, beautiful, and every man falls ineluctably in love with/lusts after her. It is too much. Similarly, after three volumes and 1200 pages, it is clear that Elena is stuck on the womanizer Nino, but I defy anyone to tell me why. There is no basis for it outside of Elena’s psyche, and she is not sharing that with us.
The action is melodramatic, operatic. The attempts at explanation of the ladies’ feelings are sophistical.
Ashes Ashes Trilogy Series 1 by Ilsa J Bick where those left standing must learn what a backpacking trip in the wilderness when something unexpected and terrifying happens ndash Angelfall Penryn and the End of Days Series 1 by It will satisfy those looking for Susan Ee has said there should be about five books in the Penryn and the End of Days series ndash Susan Ee continued to Bones TV Series 2005 IMDb Booth struggles to protect those closest to him Bones 2005 browse photos track your Watchlist and rate your favorite movies and TV shows on your
Download Those Who Leave and Those Who Stay Audible – Unabridged ridged Free PDF
Drums of Autumn (Outlander) Mass Market Paperback – November 10, 1997
Author: Visit ‘s Diana Gabaldon Page ID: 044022425X
.com Review
Set in pre-Revolutionary War America, readers finally have the much awaited fourth book in what will probably become a six book series (The Outlander series). The talented Diana Gabaldon continues Claire and Jamie’s romantic love affair, and introduces Brianna and Roger’s story. Eight hundred pages, and several wonderful new characters later, we wonder why we were waiting for a conclusion. It’ll be a long wait for book five, so I recommend you go back and reread Outlander, Dragonfly in Amber, and Voyager to keep yourself sane.
–This text refers to the Hardcover edition.
From Publishers Weekly
Gabaldon has few rivals in writing exciting?and hefty?historical romances. The fourth in a series of linked sagas (Outlander; Dragonfly in Amber; Voyager), her new epic has a delicious premise. Claire Randall, the post-WWII bride of historian Frank Randall, steps through a skew in the Scottish stone circle Craigh na Dun and lands in Revolutionary America and the arms of Highlander Jamie Fraser?putting a new spin on the notion of a two-timing woman. Bold and bawdy, but a believing Catholic, Claire struggles to live a rich and moral life?or, rather, rich and moral lives?under these extraordinary circumstances. Claire’s adventures in 18th-century Charleston alternate with equally engaging chapters devoted to her 20th-century daughter, Brianna. Raised as Frank Randall’s child, Bree discovers that Jamie Fraser is her real sire. She takes off on a harrowing, confrontational quest through time and space with her suitor, Roger Wakefield, in hot pursuit. Gabaldon’s range is impressive, whether she’s evoking the rawness of colonial America, the cozy clutter of a modern Scottish parsonage, the lusts of the body or the yearnings of the spirit. Her legion of fans will love diving into this ocean of romance. Major ad/promo; Literary Guild and Doubleday Book Club featured alternates; author tour.
Copyright 1996 Reed Business Information, Inc.
–This text refers to the Hardcover edition.
See all Editorial Reviews
Series: Outlander (Book 4)Mass Market Paperback: 1070 pagesPublisher: Dell Publishers; Reissue edition (1997)Language: EnglishISBN-10: 044022425XISBN-13: 978-0440224259 Product Dimensions: 4.2 x 1.8 x 6.9 inches Shipping Weight: 15.2 ounces (View shipping rates and policies) Best Sellers Rank: #1,362 in Books (See Top 100 in Books) #20 in Books > Romance > Historical > Scottish #30 in Books > Romance > Time Travel #42 in Books > Literature & Fiction > Genre Fiction > Historical > Fantasy
Ostensibly, "Drums of Autumn" is about reunions with fathers. Gabaldon, however, seems to meander about quite a bit before she remembers her theme. Although I didn’t do an exact count, I agree with the reviewer who commented that the first 500 pages are terrible. "Drums" begins with Jamie and Claire attending the execution of one of Jamie’s fellow inmates. Jamie and Claire, plus entourage, are heading to a Scottish settlement in Wilmington, North Carolina, where his aunt owns a plantation. The first half of the book mostly involves the mishaps on their journey north, life at the aunt’s plantation, Jamie’s debate over whether to strike out on his own or accept his aunt’s generous offer, an adventure-filled trip to the wilderness, and ultimately, getting settled in a home in the new world.
While I don’t want to suggest that all these events are mundane–this is Jamie and Claire Fraser we’re talking about, after all–the events are very episodic. Gabaldon lacks any kind of overriding theme to organize the plot. In "Outlander," we had Claire’s ultimate decision about whether to return to her 20th century life. In "Dragonfly in Amber," we had their attempt to prevent Culloden. In "Voyager," we first had Claire’s search for records of what happened to Jamie, and later the search and rescue of Jamie’s nephew Ian.
Also missing in "Drums" is a good villain. With the deaths of Jack Randall and Geillis Duncan, Gabaldon has to create a new bad guy or two. She does introduce her villains fairly early on–only their true malevolence does not become apparent until much later.
This is the fourth in a series of what has been, until now, exceptionally well written time travel, adventure/romance books by the author. There are four such books published to date in what is anticipated to be a series of six books. Those of us who are hopelessly addicted to this series are awaiting the publication and release of book five, "The Fiery Cross".
I urge the reader to start at the beginning and read each and every one in the order in which it was written. Be not afraid of the length of each book. Trust me when I say that you will end up wishing that they were each longer, so riveting is the story that the author unfolds. Ms. Gabaldon is a master storyteller without compare, employing the superlative use of actual historical events with authentic period detail to weave a three dimensional tapestry of timeless love and adventure. While the core of the story is about a love that transcends time, it is an adventure story that holds the reader in its thrall.
The love that spans time is that which twentieth century Englishwoman, Claire Randall, has for eighteenth century Scottish highlands warrior, James Fraser. Those readers who have read the first book in the series, "Outlander", know that in 1945, Claire, a combat nurse during World War II, is reunited with her husband, Frank, after the war. While on a second honeymoon in Scotland, she visits a strange, flat topped hill, where a forbidding stone circle draws her. Touching one of the stones, she is hurled through a vortex in time and finds herself in eighteenth century Scotland, where she meets the brave and brawny, red headed Scot, James Fraser, with whom she falls head over heels in love.
"Drums Of Autumn" is the fourth book in Diana Gabaldon’s extraordinary "Outlander" series. It amazes me that Ms. Gabaldon has been able to continue to delight readers with her consistently good writing, excellent plots, superb characters and meticulous historic research for thousands of pages and four novels. "Drums Of Autumn" most certainly will not disappoint fans of the series. If you have not read the three preceding novels, I strongly urge you to do so before beginning this book. "Drums of Autumn" may be able to stand as a novel in its own right, but I think it would be too confusing to enjoy it thoroughly without having read the historic and personal drama that Ms. Gabaldon details so well in her previous books. To label the "Outlander" series as merely historical romance fiction would be to do it a terrible injustice. This is an epic historical romance, yes…and so much more. The relationship between Claire and Jamie is one of the most caring and intimate I have ever encountered – in fiction or real life. This is a couple who are solidly committed to a life together for better or worse. Theirs is a love that truly transcends the boundaries of time.
More than twenty years before this novel begins, Claire Beauchamps Randall, vacationing in post WWII Scotland, stepped through the ancient stone circle known as Craigh na Dun – and was suddenly sucked back in time to 1743 and war-torn Scotland. It was here that she met and married her own true love, highlander James Fraser. Before the tragic battle of Culloden Moor she was forced to return to the 20th century to protect herself and her unborn daughter, abandoning Jamie in the process. Download Drums of Autumn Mass Market – November 10, 1997 Free PDF
Drums of Autumn (Outlander) Mass Market Paperback – November 10, 1997
Author: Visit ‘s Diana Gabaldon Page ID: 044022425X
.com Review
Set in pre-Revolutionary War America, readers finally have the much awaited fourth book in what will probably become a six book series (The Outlander series). The talented Diana Gabaldon continues Claire and Jamie’s romantic love affair, and introduces Brianna and Roger’s story. Eight hundred pages, and several wonderful new characters later, we wonder why we were waiting for a conclusion. It’ll be a long wait for book five, so I recommend you go back and reread Outlander, Dragonfly in Amber, and Voyager to keep yourself sane.
–This text refers to the Hardcover edition.
From Publishers Weekly
Gabaldon has few rivals in writing exciting?and hefty?historical romances. The fourth in a series of linked sagas (Outlander; Dragonfly in Amber; Voyager), her new epic has a delicious premise. Claire Randall, the post-WWII bride of historian Frank Randall, steps through a skew in the Scottish stone circle Craigh na Dun and lands in Revolutionary America and the arms of Highlander Jamie Fraser?putting a new spin on the notion of a two-timing woman. Bold and bawdy, but a believing Catholic, Claire struggles to live a rich and moral life?or, rather, rich and moral lives?under these extraordinary circumstances. Claire’s adventures in 18th-century Charleston alternate with equally engaging chapters devoted to her 20th-century daughter, Brianna. Raised as Frank Randall’s child, Bree discovers that Jamie Fraser is her real sire. She takes off on a harrowing, confrontational quest through time and space with her suitor, Roger Wakefield, in hot pursuit. Gabaldon’s range is impressive, whether she’s evoking the rawness of colonial America, the cozy clutter of a modern Scottish parsonage, the lusts of the body or the yearnings of the spirit. Her legion of fans will love diving into this ocean of romance. Major ad/promo; Literary Guild and Doubleday Book Club featured alternates; author tour.
Copyright 1996 Reed Business Information, Inc.
–This text refers to the Hardcover edition.
See all Editorial Reviews
Series: Outlander (Book 4)Mass Market Paperback: 1070 pagesPublisher: Dell Publishers; Reissue edition (1997)Language: EnglishISBN-10: 044022425XISBN-13: 978-0440224259 Product Dimensions: 4.2 x 1.8 x 6.9 inches Shipping Weight: 15.2 ounces (View shipping rates and policies) Best Sellers Rank: #1,362 in Books (See Top 100 in Books) #20 in Books > Romance > Historical > Scottish #30 in Books > Romance > Time Travel #42 in Books > Literature & Fiction > Genre Fiction > Historical > Fantasy
Ostensibly, "Drums of Autumn" is about reunions with fathers. Gabaldon, however, seems to meander about quite a bit before she remembers her theme. Although I didn’t do an exact count, I agree with the reviewer who commented that the first 500 pages are terrible. "Drums" begins with Jamie and Claire attending the execution of one of Jamie’s fellow inmates. Jamie and Claire, plus entourage, are heading to a Scottish settlement in Wilmington, North Carolina, where his aunt owns a plantation. The first half of the book mostly involves the mishaps on their journey north, life at the aunt’s plantation, Jamie’s debate over whether to strike out on his own or accept his aunt’s generous offer, an adventure-filled trip to the wilderness, and ultimately, getting settled in a home in the new world.
While I don’t want to suggest that all these events are mundane–this is Jamie and Claire Fraser we’re talking about, after all–the events are very episodic. Gabaldon lacks any kind of overriding theme to organize the plot. In "Outlander," we had Claire’s ultimate decision about whether to return to her 20th century life. In "Dragonfly in Amber," we had their attempt to prevent Culloden. In "Voyager," we first had Claire’s search for records of what happened to Jamie, and later the search and rescue of Jamie’s nephew Ian.
Also missing in "Drums" is a good villain. With the deaths of Jack Randall and Geillis Duncan, Gabaldon has to create a new bad guy or two. She does introduce her villains fairly early on–only their true malevolence does not become apparent until much later.
This is the fourth in a series of what has been, until now, exceptionally well written time travel, adventure/romance books by the author. There are four such books published to date in what is anticipated to be a series of six books. Those of us who are hopelessly addicted to this series are awaiting the publication and release of book five, "The Fiery Cross".
I urge the reader to start at the beginning and read each and every one in the order in which it was written. Be not afraid of the length of each book. Trust me when I say that you will end up wishing that they were each longer, so riveting is the story that the author unfolds. Ms. Gabaldon is a master storyteller without compare, employing the superlative use of actual historical events with authentic period detail to weave a three dimensional tapestry of timeless love and adventure. While the core of the story is about a love that transcends time, it is an adventure story that holds the reader in its thrall.
The love that spans time is that which twentieth century Englishwoman, Claire Randall, has for eighteenth century Scottish highlands warrior, James Fraser. Those readers who have read the first book in the series, "Outlander", know that in 1945, Claire, a combat nurse during World War II, is reunited with her husband, Frank, after the war. While on a second honeymoon in Scotland, she visits a strange, flat topped hill, where a forbidding stone circle draws her. Touching one of the stones, she is hurled through a vortex in time and finds herself in eighteenth century Scotland, where she meets the brave and brawny, red headed Scot, James Fraser, with whom she falls head over heels in love.
"Drums Of Autumn" is the fourth book in Diana Gabaldon’s extraordinary "Outlander" series. It amazes me that Ms. Gabaldon has been able to continue to delight readers with her consistently good writing, excellent plots, superb characters and meticulous historic research for thousands of pages and four novels. "Drums Of Autumn" most certainly will not disappoint fans of the series. If you have not read the three preceding novels, I strongly urge you to do so before beginning this book. "Drums of Autumn" may be able to stand as a novel in its own right, but I think it would be too confusing to enjoy it thoroughly without having read the historic and personal drama that Ms. Gabaldon details so well in her previous books. To label the "Outlander" series as merely historical romance fiction would be to do it a terrible injustice. This is an epic historical romance, yes…and so much more. The relationship between Claire and Jamie is one of the most caring and intimate I have ever encountered – in fiction or real life. This is a couple who are solidly committed to a life together for better or worse. Theirs is a love that truly transcends the boundaries of time.
More than twenty years before this novel begins, Claire Beauchamps Randall, vacationing in post WWII Scotland, stepped through the ancient stone circle known as Craigh na Dun – and was suddenly sucked back in time to 1743 and war-torn Scotland. It was here that she met and married her own true love, highlander James Fraser. Before the tragic battle of Culloden Moor she was forced to return to the 20th century to protect herself and her unborn daughter, abandoning Jamie in the process. Download Drums of Autumn Mass Market – November 10, 1997 Free PDF
Data Monitoring Committees in Clinical Trials: A Practical Perspective (Statistics in Practice) Kindle Edition
Author: Susan S. Ellenberg ID: B000PY456G
Done.
File Size: 2278 KBPrint Length: 208 pagesPublisher: Wiley; 1 edition (December 10, 2007)Publication Date: December 10, 2007 Sold by: Digital Services, Inc. Language: EnglishID: B000PY456GText-to-Speech: Enabled X-Ray: Not Enabled Word Wise: Not EnabledLending: Not Enabled Enhanced Typesetting: Not Enabled Best Sellers Rank: #1,214,511 Paid in Kindle Store (See Top 100 Paid in Kindle Store) #1153 in Kindle Store > Kindle eBooks > Nonfiction > Science > Mathematics > Applied > Probability & Statistics #8190 in Books > Science & Math > Mathematics > Applied > Probability & Statistics #500720 in Books > Reference
Susan Ellenberg is a Professor of Biostatistics at the University of Pennsylvania. Prior to that she played a prominent role in the development of statistical methods for clinical trials at the US Food and Drug Administration. She made major contributions to the Harmonization Committee’s ICH Guidelines on statistical methods in clinical trials, particularly the Guideline E9.
Tom Fleming and David DeMets are Professor of Biostatistics at University of Washington and Wisconsin University respectively. They are among the world’s leading experts in group sequential methods. Fleming is famous for the O’Brien-Fleming stopping rule that bears his name and DeMets is known for the Lan-DeMets alpha spending function approach to group sequential analysis.
With such experts and excellent writers you get what you should expec t, an authoritative treatment of the practical and technical aspects of the monitoring of data by Data Monitoring Committees (DMCs, previously called Data Safety and Monitoring Boards, DMSBs). These committees look at interim data from a clinical trial to judge whether the trial should be stopped early for safety concerns. In their charter they can set-up their own rule or can debate and make subjective decisions. These authors through their experience present examples and also formal statistical methods that can be used not only to stop for safety concerns but also to stop if safety and efficacy are demonstrated earlier than anticipated in the design. Also if the trial is clearly going to be unsuccessful they can stop for futility as well.
The development of group sequential methods and adaptive designs make a formal analysis for the DMC possible. For a detailed account of group sequential methods see the book by Jennison and Turnbull. Download Data Monitoring Committees in Clinical Trials: A Practical Perspective Kindle Edition Pdf Download
Data Monitoring Committees in Clinical Trials: A Practical Perspective (Statistics in Practice) Kindle Edition
Author: Susan S. Ellenberg ID: B000PY456G
Done.
File Size: 2278 KBPrint Length: 208 pagesPublisher: Wiley; 1 edition (December 10, 2007)Publication Date: December 10, 2007 Sold by: Digital Services, Inc. Language: EnglishID: B000PY456GText-to-Speech: Enabled X-Ray: Not Enabled Word Wise: Not EnabledLending: Not Enabled Enhanced Typesetting: Not Enabled Best Sellers Rank: #1,214,511 Paid in Kindle Store (See Top 100 Paid in Kindle Store) #1153 in Kindle Store > Kindle eBooks > Nonfiction > Science > Mathematics > Applied > Probability & Statistics #8190 in Books > Science & Math > Mathematics > Applied > Probability & Statistics #500720 in Books > Reference
Susan Ellenberg is a Professor of Biostatistics at the University of Pennsylvania. Prior to that she played a prominent role in the development of statistical methods for clinical trials at the US Food and Drug Administration. She made major contributions to the Harmonization Committee’s ICH Guidelines on statistical methods in clinical trials, particularly the Guideline E9.
Tom Fleming and David DeMets are Professor of Biostatistics at University of Washington and Wisconsin University respectively. They are among the world’s leading experts in group sequential methods. Fleming is famous for the O’Brien-Fleming stopping rule that bears his name and DeMets is known for the Lan-DeMets alpha spending function approach to group sequential analysis.
With such experts and excellent writers you get what you should expec t, an authoritative treatment of the practical and technical aspects of the monitoring of data by Data Monitoring Committees (DMCs, previously called Data Safety and Monitoring Boards, DMSBs). These committees look at interim data from a clinical trial to judge whether the trial should be stopped early for safety concerns. In their charter they can set-up their own rule or can debate and make subjective decisions. These authors through their experience present examples and also formal statistical methods that can be used not only to stop for safety concerns but also to stop if safety and efficacy are demonstrated earlier than anticipated in the design. Also if the trial is clearly going to be unsuccessful they can stop for futility as well.
The development of group sequential methods and adaptive designs make a formal analysis for the DMC possible. For a detailed account of group sequential methods see the book by Jennison and Turnbull. Download Data Monitoring Committees in Clinical Trials: A Practical Perspective Kindle Edition Pdf Download
